Semax
Molecular Formula: C37H51N9O10S
Molecular Weight: ~869.9 g/mol
Sequence: Met-Glu-His-Phe-Pro-Gly-Pro
Form: Lyophilized peptide, ≥98% purity
Synonyms: ACTH(4–7) analog, Heptapeptide Semax
Overview
Semax is a synthetic heptapeptide derived from a fragment of adrenocorticotropic hormone (ACTH 4–10) with modifications to increase stability and resistance to enzymatic breakdown. Developed in Russia, Semax is primarily studied as a neuroprotective and nootropic peptide with potential roles in cognitive support, neurodegeneration research, and adaptive stress responses.
Its unique design allows it to exhibit neuromodulatory and neurotrophic properties without the hormonal effects associated with ACTH.
Mechanism of Action
In laboratory and preclinical studies, Semax is believed to act through:
Neurotrophic Modulation: Upregulates Brain-Derived Neurotrophic Factor (BDNF) and Nerve Growth Factor (NGF), supporting neuronal survival and plasticity.
Neurotransmitter Regulation: Modulates dopaminergic and serotonergic systems, influencing mood, learning, and memory.
Antioxidant Properties: Reduces oxidative stress and promotes resilience in neural tissues.
Immune Modulation: Balances pro- and anti-inflammatory cytokines, contributing to immune-neurological interactions.
Cognitive Enhancement: Enhances synaptic plasticity and cerebral blood flow in animal research models.
Research Areas
Semax has been investigated in preclinical research for:
Cognitive Function: Supporting memory, focus, and learning performance.
Stroke & Ischemia Models: Studying neuroprotection and recovery after ischemic injury.
Neurodegeneration: Exploring potential roles in Alzheimer’s, Parkinson’s, and other neurodegenerative disorders.
Stress & Mood Regulation: Evaluating anxiolytic and antidepressant-like properties in experimental models.
Visual and Sensory Research: Studied for effects on optic nerve and visual system health.
Handling & Storage
Storage (lyophilized): –20°C in a cool, dry environment, away from light.
Reconstitution: Reconstitute with sterile water or buffer.
Stability: Once reconstituted, store at 2–8°C and use within a limited period; avoid freeze–thaw cycles.
Disclaimer
Semax is intended strictly for laboratory and preclinical research use.
It is not approved for human or veterinary use and should not be used for diagnostic, therapeutic, or self-administration purposes. Research applications are limited to controlled experimental studies.
