Semaglutide
Molecular Formula: C187H291N45O59
Molecular Weight: ~4113.6 g/mol
Sequence: Modified GLP-1 (glucagon-like peptide-1) analog with substitutions for stability and prolonged half-life
Form: Lyophilized peptide, ≥98% purity
Synonyms: NN9535, GLP-1 receptor agonist analog
Overview
Semaglutide is a synthetic analog of glucagon-like peptide-1 (GLP-1), a naturally occurring incretin hormone that plays a role in glucose metabolism and appetite regulation. Through chemical modifications, Semaglutide achieves a longer half-life and enhanced stability, allowing for sustained biological activity compared to native GLP-1.
In research, Semaglutide is studied for its metabolic, weight-regulating, and glucose-modulating effects, making it a leading subject in metabolic disease and obesity research.
Mechanism of Action
Research suggests Semaglutide functions by:
GLP-1 Receptor Activation: Enhances insulin secretion and suppresses glucagon in glucose-dependent contexts.
Appetite Regulation: Influences hypothalamic signaling, reducing food intake in experimental models.
Gastric Emptying Delay: Slows stomach emptying, aiding in satiety and controlled glucose absorption.
Cardiovascular Modulation: Demonstrates potential to improve endothelial function and lipid metabolism in animal studies.
Extended Half-Life: Modified with fatty acid side chain binding to albumin, reducing degradation and prolonging systemic activity.
Research Areas
Semaglutide is currently being investigated in preclinical and translational research for:
Obesity & Weight Management Models: Exploring its role in appetite suppression and energy balance.
Type 2 Diabetes Research: Evaluating glucose regulation and insulin sensitivity.
Cardiovascular Studies: Investigating effects on endothelial health, lipid regulation, and inflammation.
Neuroprotective Research: Early studies suggest possible roles in cognitive and neurodegenerative models linked to metabolic dysfunction.
Handling & Storage
Storage (lyophilized): –20°C in a cool, dry environment protected from light.
Reconstitution: Dissolve with sterile water or buffer before use.
Stability: Store reconstituted solution at 2–8°C and use promptly; avoid repeated freeze–thaw cycles.
Disclaimer
Semaglutide is intended exclusively for laboratory and preclinical research purposes.
It is not approved for human or veterinary consumption and should not be used in diagnostic, therapeutic, or self-administration settings. Research applications remain restricted to controlled experimental environments.
