5-Amino-1MQ
Molecular Formula: C10H11N2+
Molecular Weight: ~159.21 g/mol
Form: Lyophilized powder, ≥98% purity
Synonyms: 5-Amino-1-methylquinolinium, NNMT inhibitor compound
Overview
5-Amino-1MQ is a small-molecule compound studied for its ability to inhibit Nicotinamide N-methyltransferase (NNMT), an enzyme involved in cellular metabolism, energy regulation, and fat storage. NNMT overexpression has been linked to obesity, metabolic dysfunction, and certain cancers, making 5-Amino-1MQ an important tool in metabolic and oncology research.
By suppressing NNMT activity, 5-Amino-1MQ may help improve NAD+ availability, mitochondrial function, and energy expenditure, providing insights into how metabolic pathways can be modulated for therapeutic benefit.
Mechanism of Action
In research models, 5-Amino-1MQ functions by:
NNMT Inhibition: Blocks the conversion of nicotinamide to 1-methylnicotinamide, preserving NAD+ pools.
Enhanced NAD+ Metabolism: Supports sirtuin and PARP activity by maintaining NAD+ levels.
Mitochondrial Support: Improves energy utilization and metabolic efficiency in preclinical studies.
Adipose Tissue Effects: Promotes fat metabolism and reduced adiposity in experimental models.
Cellular Regulation: Influences gene expression and epigenetic signaling pathways linked to metabolism.
Research Areas
5-Amino-1MQ is under investigation in preclinical research for:
Obesity & Weight Management: Studying its role in reducing adipose tissue and regulating energy balance.
Metabolic Disorders: Exploring benefits in insulin resistance, type 2 diabetes, and dyslipidemia models.
NAD+ Metabolism: Evaluating synergistic effects with NAD+ precursors in longevity and energy research.
Oncology: Researching NNMT inhibition in tumor growth, metastasis, and cancer metabolism.
Aging & Longevity Studies: Investigating its role in cellular resilience and metabolic health across aging models.
Handling & Storage
Storage (lyophilized): –20°C in a cool, dry environment, away from light.
Reconstitution: Dissolve with sterile solvent suitable for laboratory use.
Stability: Store reconstituted solution at 2–8°C; avoid multiple freeze–thaw cycles.
Disclaimer
5-Amino-1MQ is intended strictly for laboratory and preclinical research purposes.
It is not approved for human or veterinary use and should not be used for diagnosis, treatment, or self-administration. All applications are restricted to controlled scientific research environments.
