GHK-Cu (Copper Tripeptide-1)
Molecular Formula: C14H24N6O4 • Cu
Molecular Weight: ~ 403.9 g/mol (as copper complex)
Form: Lyophilized powder, ≥98% purity
Synonyms: Copper Tripeptide-1, Glycyl-L-histidyl-L-lysine:Cu²⁺
Overview
GHK-Cu, also known as Copper Tripeptide-1, is a naturally occurring copper-binding peptide first identified in human plasma. Found in tissues and fluids such as saliva and urine, its concentration declines with age, making it a major focus of skin rejuvenation and tissue repair research.
Extensively studied since the 1970s, GHK-Cu is recognized for its ability to stimulate collagen production, enhance skin elasticity, promote wound healing, and protect against oxidative stress. Its reputation as a regenerative compound makes it a valuable tool in preclinical research across dermatology, anti-aging, and tissue repair fields.
Mechanism of Action
In research models, GHK-Cu functions by delivering bioavailable copper ions into cells, which activate enzymes and signaling pathways essential for repair and regeneration.
Key mechanisms include:
Collagen & ECM Remodeling: Stimulates fibroblasts to produce collagen, elastin, and glycosaminoglycans.
Wound Healing: Enhances cellular migration and accelerates tissue regeneration.
Antioxidant Defense: Upregulates protective enzymes like superoxide dismutase (SOD).
Anti-Inflammatory Modulation: Reduces pro-inflammatory cytokines, aiding tissue recovery.
Angiogenesis Support: Promotes new blood vessel formation for improved oxygen and nutrient delivery.
Research Areas
GHK-Cu is studied in preclinical research for:
Skin Regeneration & Anti-Aging: Investigating wrinkle reduction, improved elasticity, and skin tone.
Wound Healing: Exploring accelerated tissue repair and reduced scarring in experimental models.
Hair Growth: Studying stimulation of hair follicle regeneration.
Organ & Tissue Repair: Evaluating protective and restorative effects in nerves, lungs, and other tissues.
Oxidative Stress Protection: Researching its role in cellular defense against environmental stressors.
Handling & Storage
Storage (lyophilized): –20°C, dry and away from light.
Reconstitution: Reconstitute with sterile or bacteriostatic water. Store solution at 2–8°C.
Stability: Avoid repeated freeze–thaw cycles.
Disclaimer
GHK-Cu is provided strictly for laboratory and preclinical research use only.
It is not approved for human or veterinary use, cosmetic application, or therapeutic treatment. No clinical data confirms its safety or efficacy in humans.
