Selank
Molecular Formula: C33H57N11O9
Molecular Weight: ~751.9 g/mol
Sequence: Thr-Lys-Pro-Arg-Pro-Gly-Pro
Form: Lyophilized peptide, ≥98% purity
Synonyms: TP-7, Synthetic heptapeptide analog of tuftsin
Overview
Selank is a synthetic heptapeptide derived from tuftsin, a natural immunomodulatory peptide. It was developed by the Institute of Molecular Genetics of the Russian Academy of Sciences as a nootropic and anxiolytic research peptide.
In research settings, Selank has demonstrated potential effects on mood regulation, learning, memory, and immune system modulation. Its stability and long-lasting activity compared to natural tuftsin make it an attractive subject in neuropsychopharmacological studies.
Mechanism of Action
Selank’s proposed mechanisms in laboratory research include:
Neurotransmitter Modulation: Influences GABAergic signaling, contributing to anxiolytic and calming effects.
Monoamine Regulation: May help balance dopamine and serotonin levels in neural models.
Immune System Effects: Enhances IL-6 expression and modulates cytokine balance, supporting immune research.
Neuroprotection: Exhibits antioxidant and neurotrophic properties, potentially reducing oxidative stress in neurons.
Cognitive Support: Stimulates BDNF (Brain-Derived Neurotrophic Factor), aiding in synaptic plasticity and memory research.
Research Areas
Selank is under investigation in preclinical and experimental studies for:
Anxiety & Stress Models: Evaluating its ability to reduce anxiety-like behavior.
Cognitive Function: Studying improvements in learning, focus, and memory.
Mood Regulation: Exploring its potential role in balancing neurotransmitters in depression models.
Immune Modulation: Researching effects on cytokine activity and overall immune response.
Neuroprotection: Investigating resilience against oxidative and neurodegenerative stress.
Handling & Storage
Storage (lyophilized): –20°C in a cool, dry place protected from light.
Reconstitution: Reconstitute with sterile water or buffer.
Stability: Store reconstituted solution at 2–8°C and use promptly; avoid repeated freeze–thaw cycles.
Disclaimer
Selank is intended solely for laboratory and preclinical research use.
It is not approved for human or veterinary use and should not be used for diagnosis, treatment, or self-administration. Experimental applications remain limited to controlled research environments.
