TB-500 (Thymosin Beta-4 Fragment)
Molecular Formula: C₁₂₉H₂₁₆N₄₀O₅₁
Molecular Weight: 3352.48 g/mol
Form: Lyophilized powder (5mg, ≥99% purity)
Synonyms: TB-500, TB4 (17–23) fragment
Overview
TB-500 (TB4 17–23) is a synthetic fragment of Thymosin Beta-4 (TB4), a naturally occurring peptide found in all human and mammalian cells. TB4 plays a central role in the body’s natural healing process, and TB-500 has been developed to capture its most important regenerative properties.
Researchers are particularly interested in TB-500 because of its ability to regulate actin, a protein essential for cell movement and structure. By influencing this process, TB-500 is widely studied for its potential to support wound healing, tissue repair, and angiogenesis (new blood vessel formation).
How It Works
In laboratory studies, TB-500 has been shown to interact with G-actin, helping to reorganize cell structures and improve cell movement. This activity supports faster and more effective healing responses in preclinical settings.
Research has highlighted TB-500’s ability to:
Encourage cell migration and proliferation, essential for tissue recovery.
Stimulate angiogenesis, improving blood supply to injured areas.
Reduce inflammation by lowering pro-inflammatory signals.
Protect damaged cells from apoptosis (cell death).
Support extracellular matrix remodeling, helping new tissue replace old or damaged areas.
Some studies also suggest TB-500 may play a role in stem cell differentiation, opening new possibilities in regenerative research.
Research Areas
TB-500 has become a popular focus of study in preclinical research, with potential applications in:
Muscle and tendon repair – speeding up recovery in animal models.
Skin and wound healing – promoting faster closure and reduced scarring.
Cardiovascular studies – stimulating blood vessel growth in ischemic tissues.
Inflammatory research – reducing cytokine-driven inflammation.
Hair growth studies – investigating effects on follicle activity and regeneration.
Handling & Storage
Supplied in sterile lyophilized 5mg vials (≥99% purity).
Storage: Keep lyophilized vials at –20°C, away from light and moisture. Once reconstituted with bacteriostatic water, store refrigerated (2–8°C).
Disclaimer
TB-500 is intended exclusively for laboratory and preclinical research purposes. It is not approved for human or veterinary use. There is currently no clinical evidence supporting its safety or effectiveness in humans.
