Tesamorelin
Molecular Formula: C221H366N72O67S
Molecular Weight: ~5108.9 g/mol
Sequence: A synthetic 44–amino acid peptide analog of Growth Hormone–Releasing Hormone (GHRH)
Form: Lyophilized peptide, ≥98% purity
Synonyms: TH9507, GHRH(1-44) analog
Overview
Tesamorelin is a synthetic peptide analog of Growth Hormone–Releasing Hormone (GHRH) designed to stimulate the natural secretion of growth hormone (GH). By mimicking endogenous GHRH, Tesamorelin has been widely studied for its effects on lipid metabolism, muscle preservation, and growth hormone regulation.
In research, Tesamorelin demonstrates promise in modulating fat distribution, improving body composition, and supporting metabolic health. Its stability and potency make it an important tool in growth hormone–related studies.
Mechanism of Action
In laboratory models, Tesamorelin acts by:
Binding to GHRH Receptors: Stimulates the pituitary gland to release endogenous growth hormone.
IGF-1 Elevation: Increases insulin-like growth factor-1 (IGF-1) levels, which mediate many anabolic and metabolic effects.
Fat Metabolism: Enhances lipolysis and reduces visceral adipose tissue in experimental studies.
Protein Synthesis Support: Promotes muscle preservation and regeneration via GH–IGF-1 pathways.
Endocrine Regulation: Mimics natural pulsatile GH release, supporting a more physiologic hormone rhythm.
Research Areas
Tesamorelin has been studied in preclinical and translational research for:
Adipose Tissue Research: Investigating effects on visceral and subcutaneous fat metabolism.
Muscle Preservation: Evaluating its role in muscle mass maintenance during aging or catabolic states.
Metabolic Disorders: Exploring applications in insulin sensitivity, lipid regulation, and obesity models.
Growth Hormone Deficiency: Studying its potential as a growth hormone secretagogue in deficiency models.
Aging & Longevity Research: Investigating GH/IGF-1 axis effects on aging and regenerative processes.
Handling & Storage
Storage (lyophilized): –20°C in a cool, dry environment away from direct light.
Reconstitution: Reconstitute with sterile water for research applications.
Stability: Store reconstituted solution at 2–8°C; avoid freeze–thaw cycles and use within designated stability period.
Disclaimer
Tesamorelin is intended exclusively for laboratory and preclinical research purposes.
It is not approved for human or veterinary consumption and should not be used in diagnostic, therapeutic, or self-administration contexts. Research applications must remain restricted to controlled scientific settings.
